![]() ![]() In regard to these biomarkers, it is difficult to separate EVs from serum or plasma, and the protein in the background may be interferential. The biomarkers in peripheral blood, such as circulating tumor cells (CTCs), extracellular vesicles (EVs), cell-free nucleic acids (cfNAs), and tumor-educated platelets (TEPs), could be detected as tumor-associated components. For example, liquid biopsy, which is quick and non-invasive, could be a potential alternative detection method for early cancer diagnosis. A more accurate and non-invasive cancer diagnosis is attracting great attention. However, the biomarkers in serum are not specific enough, and tissue biopsy may be harmful. In recent decades, cancer diagnostic modalities have been mostly based on serum screening and tissue biopsy. This simple-to-operate, low-cost chip exhibits great potential for clinical application. Moreover, we successfully identified CTCs from cancer patients’ blood samples. Our chip attained a high capture efficiency of 89.27%, a release efficiency of 91.98%, and an excellent cellular viability of 96.91% when the concentration of MMP-9 was 0.2 mg/mL. In addition, the transparency of the chip makes it possible for fluorescence immunoassay identification in situ under a microscope. ![]() These nanoparticles share a similar dimension with the microvilli and pseudopodium of the cellular surface thus, they can enhance adhesion to CTCs, and then GNPs can be degraded by the enzyme matrix metalloproteinase (MMP-9), gently releasing the captured cells. Herein, an FTO chip modified with multifunctional gelatin nanoparticles (GNPs) was designed for the specific capture and non-destructive release of CTCs. ![]() Due to their extremely low concentrations, efficient enrichment and non-destructive release are needed. Circulating tumor cells (CTCs) in cancer patients’ peripheral blood have been demonstrated to be a significant biomarker for metastasis detection, disease prognosis, and therapy response. ![]()
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![]() Likewise, our politicians, too, should stop fixating on the past. He escapes imminent death in the crumbling mansion in order to warn us of the danger of losing ourselves in the past. The protagonist’s return to the past and sojourn in Roderick Usher’s gloomy mansion has enabled him to realize the deadly consequences of renouncing the present. ![]() If you continue to live in the past, your fungi-ridden mansion will eventually collapse, and your clan will perish as well, just as Roderick Usher’s house and family did. The important thing is not to repeat the mistakes and wrongdoings of the past, not to be vindictive about the past. The “past is past,” as is said, and we should let bygones be bygones. However, such an attitude is likely to degenerate into paranoia and make the country mentally ill. Instead, they contend that they should investigate the past, claiming that our country’s past is all wrong from the beginning. Preoccupied with the past, our anachronistic politicians naturally do not have a vision for the future. Metaphorically speaking, they are living in a crumbling, haunted house that resembles Roderick Usher’s cracked, decayed mansion. They do not seem to realize that, like Roderick Usher, they are suffering acute mental illness and seeing only hallucinations of the past. Reading “The Fall of the House of Usher,” we cannot but help think about our political leaders who are also obsessed with the past, disparaging and even denouncing the present accomplishments of their country. Therefore, clinging to the past was no longer needed or valid. For American writers, the new continent America was the present and the future. Poe was one of the pioneers in the American Renaissance movement in the 19th century, through which American writers called for independence from the burden of European cultural and literary heritage, which belonged to the past. It is also noteworthy that the title of the story is “The Fall of the House of Usher” it implies both the breakdown of the Usher’s old mansion and the downfall of the Usher family. The name “Usher” is meaningful because Roderick Usher summons his childhood friend, shows him the inevitable outcome of one’s obsession with the past, and thereby “ushers” the protagonist into the present and the future. His discolored, overgrown mansion embodies his deteriorated mental state, burdened by his preoccupations with the past. ![]() Roderick Usher is completely detached from the present reality and lives in hallucinations of the past. Otherwise, the specter of bygone times will haunt us until we ruin our lives. One way to take “The Fall of the House of Usher” is to interpret it as Poe’s suggestion that if we want to have a future, we cannot cling to the past. As he hurriedly flees from the haunted place, the old mansion collapses to the ground under the ominous light of a “setting blood-red moon.” As Madeline appears in a shroud and falls over Roderick, the terrified protagonist escapes the mansion. He shudders at the horror and comes to the protagonist for comfort. Later, however, he thinks that he has buried Madeline alive by mistake because he hears his sister coming up from the basement. ![]() When Madeline dies of a strange illness, Roderick decides to bury her temporarily in the basement. The protagonist finds that Roderick has a twin sister named Madeline. ![]() Moreover, as the last descendant of the Usher family, Roderick clings to the idea of preserving his family legacy. He does not know that the times have changed and still lives in the past. The protagonist also notices that his friend is obsessed with old daydreams and fantasies, unable to cope with the present reality. Roderick is pale and extremely sensitive to noises and changes around him. Reuniting with his dear friend, the protagonist finds that he is indeed suffering from acute physical and mental illness. Minute fungi overspread the whole exterior, hanging in a fine tangled web-work from the eaves.” He writes, “The whole mansion and domain there hung an atmosphere peculiar to themselves and their immediate vicinity - an atmosphere which had no affinity with the air of heaven, but which had reeked up from the decayed trees, and the gray wall, and the silent tarn.” Then, he continues, “The discoloration of ages had been great. Metaphorically, it is a summons from the past.Īrriving at the Roderick Usher’s fungi-covered, decaying mansion, the protagonist feels a strange atmosphere. Responding to his old friend’s distress call, the protagonist travels to a distant part of the country where his friend lives. Edgar Allan Poe’s “The Fall of the House of Usher,” which was originally published in 1839, begins as the protagonist receives a letter from his close friend, Roderick Usher, who urges him to come to his house to help him as he suffers from a strange illness. ![]() ![]() ![]() It is the birthplace of commercial aviation and includes buildings that are themselves of great cultural interest, like the terminal building with its Art Deco architecture. In fact, Le Bourget is a place that all aviation heroes have been through, including Charles Lindbergh. The National Air and Space Museum maintains the world’s largest collection of historic aircraft and spacecraft. The National Air and Space Museum of France is also a site museum. The Official Air & Space Museum and Education Center of California has. It features an incredible collection of more than 400 aircraft, 150 of which are on display, from the very first aeroplanes to the Breguet 19 “Point d’Interrogation”, the Spitfire and Concorde.īridging the past and the future, the prestigious National Air and Space Museum of France is a lively place, holding events throughout the year, regularly acquiring items for the collection, hosting activities for all-including Planète Pilote for children and being hired for various events and for filming. The San Diego Air & Space Museum in Historical Balboa Park welcomes you to visit. Located within Europe’s leading business aviation airport Paris-Le Bourget, the National Air and Space Museum of France is one of the world’s finest aviation museums, both for the wealth of its collections and long history. ![]() Fly sky-high just six kilometres from Paris. Udvar-Hazy Center is the Smithsonian National Air and Space Museums (NASM) annex at Washington Dulles International Airport in Fairfax County, Virginia. ![]() ![]() It’s the end of the calendar year and they want to make their numbers. Smart companies should reward existing customers with the better deal. To exclude those like me who already pay money to your company is to annoy us. But customers like me hate offers that apply to new customers only for the companies we already do business with. Mobile phone companies are notorious at doing this. In their quest to grow revenue at any cost, many lazy marketers dream up offers to entice new users but exclude current users. Don’t exclude your existing customers in your offers I’d like to give them the benefit of the doubt here and assume that might be the case.īut it also might mean that Hightail is playing the game so many companies play: Treating existing customers like second-class citizens. Perhaps there is an error in the Hightail systems. However when I logged into my Hightail account to complete the transaction, I got a nasty error message: “Your account does not meet the pre-requisites for using this Sku code.” The offer sounded good, so I clicked the “Get the deal” button. Hightail subscription plans have confusing names: Hightail Professional is an upgrade to the Hightail Pro service I am using now. The offer promised if I “Upgrade to Hightail Professional” today, I’d get 50% off the annual subscription price. This morning I received an email offer to the address I use to subscribe to Hightail with the subject line “Complete your list with our great discount.” I’ve been a loyal customer since January 2009, paying over $100 a year for my premium services. I’m a “Pro” user of the Hightail (formerly YouSendIt) file sharing and storage service. ![]() ![]() The idea is everyone takes on an equal share of the debt and plays through each round with the goal of working together to carry the load and incrementally decrease everyone’s debt at the same time, therefore supporting each other and ensuring everyone leaves with the group’s collective debt having been cleared (squids are known for being good friends fyi, very symbolic, very deep, yes, yes). God Yuichi and his friends, Tsundere Shiho, Glasses Tenji, Bleached Hair Shibe, and Yanderedere Kokorogi, are kidnapped and told they were all enlisted to play the game against their will when one of them secretly went behind everyone else’s back and applied to play because they were in serious debt. Anyway, the show begins with all the characters apparently suffering acute brain damage. I know Japanese is kind of a confusing language to wrap your head around sometimes, but I think knowing the real title is “Squid Game” should get everyone on the same page. Instead of taking the time to explain the Tomodachi Game in detail, I should probably just explain the fact that “tomodachi” is the Japanese word for “squid,” so the English title of “Friends Game” is actually quite deceptive. And who is God Yuichi, you ask? Well, strap in motherfuckers, because every meaningless conflict in this string of meaningless conflicts can all be traced directly back to the characters, who, I think it goes without saying, are all magnificently well-written. scene which just flickered before your dry, reddish eyes. The whole show is a giant torture chamber where your brain is numbed into submission, tasked with juggling endless exposition dumps, convoluted rule sets, and seemingly random plot twists, only to be told, in fact, everything you just mulled over was irrelevant, because God Yuichi is here to retroactively change the implications of every But as their concealed feelings and problematic pasts begin to surface, their seemingly unbreakable bond may soon shatter into irreparable pieces.īeing a complete, soul-crushing waste of time isn’t exactly a new and exciting development as far as bad anime is concerned, but what’s so infuriating about this show in particular is how it serves as perhaps the single most unholy combination of pointlessness and tediousness that has ever existed in television. To pay off the amount, they must participate in a variety of psychological games that will test the true nature of their friendship and humanity.ĭistressed and isolated from the outside world, Yuuichi and his friends need to cooperate to complete the games. After waking, the group find themselves confined in a white room with controversial figure Manabu-kun, who reveals that one of the five has gathered them together to clear their personal debt of twenty million yen. Soon after, Yuuichi and his friends are deceived into meeting up and knocked unconscious by unknown assailants. ![]() However, when the funds for the upcoming school trip are stolen, the incident causes Shiho and Makoto-who had been tasked with collecting the money-to distance themselves from the rest of their class. High school student Yuuichi Katagiri cherishes his close circle of friends, composed of four classmates: Yutori Kokorogi, Shiho Sawaragi, Makoto Shibe, and Tenji Mikasa. ![]() ![]() If you're someone we might know from another community, feel free to mention that in the post! You absolutely don't need to write a pitch or anything – apart from some veterans the picks will be random. There's a forum thread in our beta section where you can throw a post at us to share your interest in participating! Log in with your Desura/IndieDB account and post whatever. We use this platform because it makes it very easy for us to gather the community and manage invites etc, as well as providing some convenient features like auto updating.Įnough with the info! Where do I sign up? For those not sure what it is, it's basically like Steam (but more lightweight). Since we want new ”first impressions” between each major update, we want to keep a portion of potential beta users on standby.Īfter the beta has begun, older applications will be picked first, so if you post before the start of the beta, you're pretty much guaranteed to get access within the first few updates. How many sort of depends on the amount of interest shown, but a majority will probably get in. A week after that we'll send out more invites. In two weeks, we'll invite 5-6 people, mainly to test out the system. NEXUS Scars of Summer ScourgeBringer Secrets of Grindea Seed of the Dead. The game isn't very long yet, as we're still in a phase where we add new features, and we want to be somewhat done with the basic framework before going into full content crunch. Clue/Cluedo: The Classic Mystery Game Conan Chop Chop Contra Anniversary. Getting 100 % completion (side quests, rare drops, cards, crafting, fishing, challenges, etc) would likely take a few hours. If you complete the side quests, up to 60 minutes. So, if what you're yearning for is the final product, a beta might not be for you!įor the average player, a playthrough where you disregard everything but the main quest would probably take about 30 minutes. The Minecraft Alpha, where you could already do a ton of stuff, and where its open ended nature meant that the alpha version was pretty much a complete game in a sense. Here at the Secrets of Grindea office we keep pressing on while dreaming of the traditional swedish christmas cuisine. It's a way for you to help us make a better game, by finding bugs, annoyances, and sharing your thoughts on what can be improved upon (and the things we've got right). ![]() Register your interest of participating in the beta! This piece of news is to inform our IndieDB-watchers that you can now ![]() ![]() ![]() But the problem is you can't order it online or go to a shop and ask them to open the box just to see which version it is.īut i was wondering for those of you who got the new reprinted version that includes all three games doesn't it also say which year it was printed on the back of the box? I currently don't have any game shops near by so i can't check for myself. If it says printed 2018 then it's obviously the original version that we want to avoid. The video says that you have to open the box and look on the disc itself on which if it's the newer version it will say "printed 2018-2019".Or "printed 2019". Even the cover of the new version is the exact same as the old one and says that it requires download of Spyro 2 & 3. However the problem is that there are still copies of the original version out there and Activision did nothing to make it easy for us to distinguish which version is which. ![]() I just happened upon this video and was pleasantly surprised to learn that Activision has (silently) reprinted the Re-ignited Trilogy and the new version includes ALL three games in the disc without the need of any patch. Continued abuse of our services will cause your IP address to be blocked indefinitely.Sorry if this was posted before.I searched but didn't find anything and i consider this big news for those of us who prefer physical and were disappointed by Activision's initial stance for this trilogy. ![]() Please fill out the CAPTCHA below and then click the button to indicate that you agree to these terms. If you wish to be unblocked, you must agree that you will take immediate steps to rectify this issue. If you do not understand what is causing this behavior, please contact us here. If you promise to stop (by clicking the Agree button below), we'll unblock your connection for now, but we will immediately re-block it if we detect additional bad behavior.
![]() ![]() It's essential for full-screen video on slower computers without native VDPAU support. Almost all other video software that runs on Linux or FreeBSD supports Xv. The accelerated scaling with just OpenGL functionality is needed mostly because of Flash player, which uses un-accelerated scaling if VDPAU is unavailable. It has been reported to work on some Intel graphics and Adobe Flash Player. Mesa as of v8.0 includes VDPAU for video cards that utilize Gallium3D.Īs of late 2013, there is an independently developed back-end driver that in turn uses OpenGL (for drawing and scaling), and VA-API if available (for decoding). Sunxi SoCs ( Allwinner) have experimental VDPAU implementation. Intel has stated they are considering VDPAU. Nvidia hopes other GPU designers will make their products compatible with the open source VDPAU library and provide drivers with VDPAU acceleration by mentioning example names of hardware specific drivers for Intel and ATI: libvdpau_intel.so and libvdpau_ati.so. It is, however, possible to use Intel's VA-API drivers by way of libvdpau-va-gl. Intel does not offer VDPAU drivers, they only support their VA-API. ĪTI/AMD released an open source driver for Radeon HD 4000+ graphic cards featuring VDPAU acceleration. As of version 14.02.17 of its Linux device driver, VDPAU is available with the S3 Chrome 430 GT, S3 Chrome 440 GTX, S3 Chrome 530 GT and the S3 Chrome 540 GTX hardware. S3 Graphics added VDPAU to the Linux drivers of their Chrome 400 video cards. VDPAU is implemented in X11 software device drivers, but relies on acceleration features in the hardware GPU.Īll Nvidia graphic cards for which the driver implements VDPAU are listed in Nvidia PureVideo. Device drivers and video controllers implementing VDPAU On March 9, 2015, Nvidia released VDPAU version 1.0 which supports High Efficiency Video Coding (HEVC) decoding for the Main, Main 4:4:4, Main Still Picture, Main 10, and Main 12 profiles. ![]() VDPAU was originally designed by Nvidia for their PureVideo SIP block present on their GeForce 8 series and later GPUs. Which specific codecs of these that can be offloaded to the GPU depends on the generation version of the GPU hardware. Ĭurrently, the portions capable of being offloaded by VDPAU onto the GPU are motion compensation (mo comp), inverse discrete cosine transform (iDCT), VLD (variable-length decoding) and deblocking for MPEG-1, MPEG-2, MPEG-4 ASP (MPEG-4 Part 2), H.264/MPEG-4 AVC and VC-1, WMV3/ WMV9 encoded videos. VDPAU allows video programs to access the specialized video decoding ASIC on the GPU to offload portions of the video decoding process and video post-processing from the CPU to the GPU. VDPAU is targeted at Unix-like operating systems (including Linux, FreeBSD, Solaris). The VDPAU interface is to be implemented by device drivers, such as Nvidia GeForce driver, nouveau, amdgpu, to offer end-user software, such as VLC media player or GStreamer, a standardized access to available video decompression acceleration hardware in the form of application-specific integrated circuit (ASIC) blocks on graphics processing units (GPU), such as Nvidia's PureVideo or AMD's Unified Video Decoder and make use of it. ![]() Video Decode and Presentation API for Unix ( VDPAU) is a royalty-free application programming interface (API) as well as its implementation as free and open-source library ( libvdpau) distributed under the MIT License. ![]() ![]() ![]() Take the last section of chenille stem and make a tail for the mouse, by taping it in place at the base of the paper mouse cone.Overlap the ends slightly and tape them together. Curl the paper so that a cone is formed by joining the two flat sides.Secure the twisted end with a piece of tape. Insert the twisted ends into the punched hole and bend them in place. Take about a 2″ section of a chenille stem for each of the ears, curl it to make a loop and then twist the ends together.Or, use paper ears which are included on the printouts and glue them on where indicated. Punch holes for the ears and tail where shown.White hole reinforcements can also be added for the eyes as shown. Paper Rat Craft from Kids Craft Room: These printable paper rats are incredibly easy to make, and you could. To add eyes for the mouse, use either google eyes or color in with a black marker. Print the blank mouse template and use it as a fun coloring sheet activity and then glue the pieces of the mouse craft together. Fun Year of the Rat Crafts for Chinese New Year.Printable Mouse Paper Bag Puppet Craft Mouse Templates (PURCHASE IN OUR SHOP) This printable mouse paper bag puppet activity is sure to add a lot of fun to your activities. If the pattern is printed on the white paper, then cut out and trace it onto colorful construction construction paper. Print the blank mouse template and use it as a fun coloring sheet activity and then glue the pieces of the mouse craft together. ![]() Print out the Printable Mouse Pattern A (prints 2 large mice) or Printable Mouse Pattern B (prints 1 large, 1 small mouse) on either white or colored printer paper.Printable Mouse Pattern A will print 2 large mice or Printable Mouse Pattern B which will print prints 1 large and 1 small mouse. ![]() ![]() Its multiple plugins and library of sounds and instruments make this program an easy sell.Pro Tools First is the free version of Pro Tools. It invites the power of a professional music studio to user desktops.Īpart from that, the industry-standard software has been around for decades and features advanced tools required for movie editing and audio recording. The software makes it easy for users to record, mix, and market their audio content. If you’ve ever used a DAW, you will find Pro Tools to be quite comprehensive. While the first two alternatives are free, Ableton offers a trial period. Some Pro Tools alternatives that you'd find of interest include Cubase, Ardour, and Ableton. However, the only drawback is that the professional version is expensive, and you may not find all the features you need in the free version. Does the Pro Tools software have any alternatives? ![]() Additionally, the tool offers easy navigation, keyboard shortcuts, and plugin support. Besides this, the software offers various modes, such as shuffle, slip, spot, and grid, that make moving audio around quite simple. You’re given access to multiple tools, so you can change the audio in its smallest waveform. With the help of this window, you can see various adjustments made via the EQ graph settings, check the RMS levels, and see the gain reduction of any plugins that you’ve installed.Įditing tracks using Pro Tools is seamless as well. The Mix window displays tracks that you’re working on vertically as if it were a mixing board. How do you use Pro Tools?Īs mentioned above, Pro Tools gives users access to two windows. The software offers simple graphics and a range of color-coding techniques to help users keep track of the changes they make. Both these windows are user-friendly and don’t overwhelm users by displaying too many features at once. The layout has changed rather little, with its features still including two minimalistic windows: one for mixing and the other for editing. Does the Pro Tools app have an easy-to-use interface? Since the tool can be quite expensive, Avid offers discounts to teachers and students. Along with a library of sounds and instruments, Ultimate lets users work with over 60 video tracks, access the Timecode Ruler, create Dolby Surround mixes, and do much more. Pro Tools Ultimate is Avid’s flagship program, designed specifically for filmmakers and professional musicians. The Standard version is quite comprehensive and gives users access to 128 audio tracks and 1024 MIDI tracks, along with features like Clip Gain Automation and Beat Detective. You can either buy the perpetual license of either of the two or opt for a monthly subscription model. Though Pro Tools First is suitable for beginners, there’s much more you can do with Pro Tools Standard and Pro Tools Ultimate. Pro Tools First gives you a total of 16 tracks, 4 simultaneous inputs, a massive instrument library, and access to an Audio Suite. However, in this version, the features and available tracks are quite limited. The first version of Pro Tools is free to download and use. ![]() Pro Tools download is available in three versions: Pro Tools First, Pro Tools Standard, and Pro Tools Ultimate. ![]() While the full version of the audio editing app is expensive, it also provides users with a free and standard version. The tool’s developer, Avid Technology, makes sure to test all new features thoroughly before rolling them out to the audience. Pro Tools download has received many updates over the years, although on an infrequent basis. For this reason, Pro Tools is considered an industry standard and used by many professional musicians and artists. Its many features make recording, editing, and publishing audio tracks a breeze. Pro Tools is a popular music software program that has been around since 1991. ![]() |